Good day!

I recently received multiple errors within my home lab when trying to vMotion Machines.

A general system occured: PBM error occurred during PreMigrateCheckCallback: Connection refused 

This is the first time i have seen this error in 6 years of Administrating a vSphere environment!

Resolution:
Various community posts pointed in the direction of a failed or not running service. in this case Profile-Drive Storage Service

(I am using the VCSA 6.0)

ssh into the VCSA
Run the following command to check the status sure enough the service was not running
service vmware-sps status

To start the service:

service vmware-sps start

Once again all VM’s are happily vmotioning around!

EDIT

I have also found the following VMware Knowledge Based Article which also could have helped – though a slightly differ ant error – KB2118557